Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase 단백질을 인식하는 기니피그 폴리클로날 항체로, 인간·마우스·랫트 반응성 확인됨. WB 및 IHC에 사용 가능하며, 신경전달물질 합성 관련 연구에 적합. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적.
- 카탈로그번호
- OST00481W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:250–1:500
Immunohistochemistry (IHC)
- Tested Dilution: 1:250–1:500
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Guinea pig / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 30–100 of human Tyrosine Hydroxylase conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: Tyrosine Hydroxylase (TH).
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine.
Catecholamine synthesis is regulated by TH interaction with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain, activating enzymatic function.
Human TH has four mRNA splice variants (hTH1–hTH4), differing in their N-terminal regulatory domains but sharing an identical catalytic domain.
TH converts L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
Its role in neurotransmitter synthesis links TH to various neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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