Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:250–1:500

Immunohistochemistry (IHC)

• Tested Dilution: 1:250–1:500

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: Tyrosine Hydroxylase (TH).

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine.
Catecholamine synthesis is regulated by TH interaction with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain, activating enzymatic function.
Human TH has four mRNA splice variants (hTH1–hTH4), differing in their N-terminal regulatory domains but sharing an identical catalytic domain.
TH converts L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
Its role in neurotransmitter synthesis links TH to various neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.