Thermo Fisher Scientific ULK1 Polyclonal Antibody
ULK1 단백질을 인식하는 sheep 유래 polyclonal antibody로, Western blot 및 IHC에 사용 가능. 인간 ULK1의 350–410 aa 합성 펩타이드 항원으로 제작. 자가포식 연구 및 mTOR 경로 분석에 적합. 장기 보관 시 -20°C에서 안정적 유지.
- 카탈로그번호
- OSU00001W
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ULK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 350–410 of human ULK1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_962401 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 150 µL of distilled water.
- Centrifuge to remove insoluble material.
- The peptide is homologous in rat and mouse.
Target Information
ULK1 is a serine/threonine protein kinase that plays a critical role during the initial stages of autophagy, a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response and rapamycin-induced autophagy, consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13, essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: OSU00001W_ULK1_O75385-1_Sheep.svg, OSU00001W_ULK1_O75385-1_Sheep_PDP.jpeg)
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