Thermo Fisher Scientific TLR2 Polyclonal Antibody
TLR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow cytometry 등 다양한 응용 가능. 인간 시료 반응성, KLH 결합 합성 펩타이드 면역원 사용. 연구용으로만 사용.
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- PA511590
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between 212–242 amino acids from the N-terminal region of human TLR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977761 |
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
TLR2 (Toll-like receptor 2) is a member of the TLR family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 can form heterodimers with TLR1 or TLR6, enabling recognition of bacterial and mycoplasma lipoproteins. TLRs are conserved from Drosophila to humans and share structural and functional similarities.
TLR2 is highly expressed in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast via NF-kappaB activation. It recognizes pathogen-associated molecular patterns (PAMPs) and promotes cytokine production for effective immunity.
TLR2 is expressed in human tonsils, microglia, lymph nodes, appendices, and activated B-cells. CD14+ monocytes show highest TLR2 expression, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.
Expression is regulated by immune modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2; IL-4, IFN-gamma, and TNF downregulate expression in monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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