Thermo Fisher Scientific SIGLEC7 Polyclonal Antibody
SIGLEC7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin) 실험에 최적화됨. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상형 항체이며, PBS/50% glycerol 용액에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIGLEC7 (Accession Q9Y286), corresponding to amino acid residues L424–K467 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900533 |
Product Specific Information
Antibody detects endogenous levels of total Siglec 7.
Target Information
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides such as disialogalactosyl globoside, disialyl lactotetraosylceramide, and disialyl GalNAc lactotetraoslylceramide.
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domains, blocking signal transduction through dephosphorylation.
Mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors toward the myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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