Thermo Fisher Scientific INSR alpha Monoclonal Antibody (83-7), Biotin
Insulin receptor alpha를 표적으로 하는 Biotin 결합 mouse monoclonal antibody입니다. ELISA, FACS, ICC/IF, IHC(P) 등 다양한 응용에 적합하며 사람, 소, 쥐 등 여러 종에 반응합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific INSR alpha Monoclonal Antibody (83-7), Biotin
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | 1 publication |
| Flow Cytometry (Flow) | Assay-dependent | 2 publications |
| ELISA | Assay-dependent | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Hamster, Human, Mouse |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 83-7 |
| Immunogen | IM-9 lymphocytes followed by IR |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_10980520 |
Additional Formats
Product Specific Information
MA5-13764 targets Insulin Receptor alpha in ELISA, FACS, ICC/IF, and IHC (P) applications and shows reactivity with Bovine, Human, Ovine, Porcine, Rat, and Rabbit samples.
The MA5-13764 immunogen is IM-9 lymphocytes followed by IR.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence in regions that confer specificity for the designated ligand and intracellular signaling domains, resulting in distinct functional consequences.
Defects in IR cause various insulin resistance syndromes, while IGF-1R defects may lead to growth retardation. Both signaling cascades are important in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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