Thermo Fisher Scientific APH1 Polyclonal Antibody
인간 및 생쥐 시료에서 APH-1 단백질을 검출하는 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 합성 펩타이드 기반 면역원으로 제작되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 11 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Hamster, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of human APH-1aL/CT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.005% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2227105 |
Product Specific Information
PA1-2010 detects APH-1 in human and mouse samples.
It has been successfully used in immunofluorescent, immunoprecipitation, and Western blot procedures.
By Western blot, this antibody detects a ~28 kDa protein representing APH-1 in mouse brain and kidney extracts.
The PA1-2010 immunogen is a synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of the C-terminal domain of the long isoform of APH-1a.
This polyclonal antibody has also been referred to as O2C2 in the reference listed above.
Target Information
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).
The gamma-secretase complex minimally consists of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B), and PEN2, although other components may exist.
APH1 likely acts as a stabilizing cofactor for the presenilin homodimer, promoting formation of a stable complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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