Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI3B2), TrueMAB
ABCB1 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 IHC(P)에서 사용 가능. 인간 시료 반응성. 친화 크로마토그래피로 정제된 액상 항체이며, 1 mg/mL 농도. 약물 내성 관련 연구 및 막단백질 발현 분석에 적합.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 347–710 of human ABCB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, which is involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates resistance to anticancer drugs. Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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