Thermo Fisher Scientific KIT Monoclonal Antibody (OTI3F9), TrueMAB
Human c-KIT 단백질(aa 546-976)을 면역원으로 제작된 Mouse monoclonal antibody. Western blot과 IHC(P)에서 검증됨. 1 mg/mL 액상형, PBS/BSA/glycerol buffer, -20°C 보관. KIT 단백질 연구 및 종양 관련 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 546–976 of human KIT produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor).
KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT and its ligand regulate the growth and activation of various hematopoietic and non-hematopoietic cells.
Mutations in KIT are associated with:
- Gastrointestinal stromal tumors (GIST)
- Mast cell disease
- Acute myelogenous leukemia
- Piebaldism
Deregulation of KIT receptor TK by the D816V mutation is a key therapeutic target in neoplastic mast cell growth.
c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract Cajal cells.
Upon binding of SCF (stem cell factor), c-Kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues (e.g., Tyr703), enabling Grb2 docking and activation of the Ras/ERK signaling pathway.
SCF/c-Kit signaling can activate PI3K, PLC-γ, and JAK/STAT pathways, essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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