
Thermo Fisher Scientific ALK Monoclonal Antibody (OTI5F4), TrueMAB
Human ALK 단백질(aa 1300-1620)에 특이적인 Rat IgG1 단클론 항체로, Western blot에 최적화되어 있음. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 뇌 발달 관련 ALK 연구 및 종양 관련 유전자 변형 분석용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene between ALK (chromosome 2) and nucleophosmin (NPM) (chromosome 5). The resulting NPM-ALK fusion protein is oncogenic.
ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, absent in the NPM-ALK fusion product, and shows high sequence similarity to LTK. ALK plays a critical role in neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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