Thermo Fisher Scientific MNK1 Polyclonal Antibody
MNK1 단백질을 검출하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 생쥐 반응성이 있으며, 액상 형태로 1 mg/mL 농도, PBS와 50% 글리세롤 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MKNK1 (Accession Q9BUB5), corresponding to amino acid residues I230–K280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900219 |
Product Specific Information
Antibody detects endogenous levels of total Mnk1.
Target Information
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may be involved in responses to environmental stress and cytokines. Expression of active MNK1 and MNK2 mutants in 293 cells reduces cap-dependent translation relative to cap-independent translation. Human Mnk2 shares ~94% identity with murine Mnk2 and 71% with human Mnk1. In vitro phosphorylation studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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