Thermo Fisher Scientific MOV10 Polyclonal Antibody
MOV10 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도 Affinity chromatography로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific MOV10 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MOV10 (Accession Q9HCE1), corresponding to amino acid residues G920–P970 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900221 |
Product Specific Information
Antibody detects endogenous levels of total Mov10.
Target Information
MOV10 is a 5′ to 3′ RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3′ UTRs. It is required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC), including both translational repression and cleavage of complementary mRNAs.
In cooperation with FMR1, MOV10 regulates miRNA-mediated translational repression by AGO2. It restricts retrotransposition of long interspersed element-1 (LINE-1) with TUT4 and TUT7, counteracting the RNA chaperone activity of L1RE1 and facilitating LINE-1 uridylation.
MOV10 is essential for embryonic viability and normal CNS development, suppressing retroelements in the nucleus and regulating cytoskeletal mRNAs for neurite outgrowth. It may act as an mRNP clearance factor and exhibits antiviral activity against dengue virus (DENV).
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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