Thermo Fisher Scientific MMP2 Polyclonal Antibody
MMP2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 등 반응. 1 mg/mL 액상 형태로 제공되며, PBS + 50% 글리세롤 버퍼에 보관. -20°C에서 안정적으로 보관 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MMP2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MMP2 (Accession P08253), corresponding to amino acid residues D618–C660. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900218 |
Product Specific Information
Antibody detects endogenous levels of total MMP2.
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix. They share a common activation mode, a conserved metal-binding active site sequence, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play essential roles in angiogenesis regulation.
MMP2 is synthesized as a 631-amino-acid proenzyme, activated by cleavage of its first 80 amino acids. It includes propeptide, catalytic, and hemopexin domains. The MMP family comprises at least eighteen secreted and membrane-bound zinc endopeptidases, collectively capable of degrading all extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.
MMP2 is involved in tissue remodeling, and mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.