Thermo Fisher Scientific PTPRG Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human PTPRG (NP_0028323) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTPRG,uniProtId:P23470-1,ncbiNodeId:9606,antigenRange:250-450,antigenLength:1445,antigenImageFileName:PA5-89705_PTPRG_P23470-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89705_PTPRG_P23470-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.53 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805736

Product Specific Information

Immunogen sequence: YRYTGSLTTP PCSEIVEWIV FRRPVPISYH QLEAFYSIFT TEQQDHVKSV EYLRNNFRPQ QRLHDRVVSK SAVRDSWNHD MTDFLENPLG TEASKVCSSP PIHMKVQPLN QTALQVSWSQ PETIYHPPIM NYMISYSWTK NEDEKEKTFT KDSDKDLKAT ISHVSPDSLY LFRVQAVCRN DMRSDFSQTM LFQANTTRIF Q; Positive Samples: A-549, 293T, Mouse kidney, Mouse heart, Mouse liver, Rat spleen; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

RPTP gamma, also known as Receptor-type tyrosine-protein phosphatase gamma, R-PTP-gamma or PTPRG is a protein tyrosine phosphatase (PTP) is a candidate tumor suppressor gene since it is located on human chromosome 3p14.2-p21, a region frequently deleted in certain types of renal and lung carcinomas. In situ hybridization analysis reveals that RPTP gamma mRNA is expressed in specific regions of the brain and that the localization of RPTP gamma changes during brain development. RPTP gamma is composed of a putative extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic tyrosine phosphatase domains. The extracellular domain contains a stretch of 266 amino acids with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), indicating that RPTP gamma and RPTP beta (HPTP zeta) represent a subfamily of receptor tyrosine phosphatases. RPTP gamma may have a function other than catalysis of hydration of metabolic CO2.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.