Thermo Fisher Scientific Desmin Polyclonal Antibody
Rabbit polyclonal antibody recognizing Desmin protein in human, mouse, and rat. Suitable for WB and IHC applications. Lyophilized form, reconstitutable in sterile water. Ideal for research on muscle cell differentiation and structure. For research use ...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of mouse Desmin conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 1000 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in human and rat.
- Specificity: Desmin.
Target Information
Desmin (~53 kDa) is a muscle-specific intermediate filament protein predominantly expressed in cardiac, skeletal, and smooth muscle cells. Its expression is regulated in a stage- and tissue-specific manner during muscle cell differentiation. In skeletal and cardiac muscle, desmin localizes to the Z-disk and intercalated disk regions. In smooth muscle, expression is more heterogeneous. Coexpression with vimentin has been observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. Altered desmin distribution is also noted in myocardial dysfunction.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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