Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Dectin-2 단백질을 인식하는 토끼 폴리클로날 항체로, 마우스 시료에 반응합니다. Western blot 및 IHC(P) 분석에 적합하며, 면역세포 내 Dectin-2 발현 연구에 유용합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse Dectin 2 conjugated to a blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Dectin-2.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production in antigen-presenting cells.
Although Dectin-2 lacks classical signaling motifs, it associates with FcRγ to activate the NF-κB pathway, promoting cytokine production. Despite sharing only 20–25% homology with Dectin-1, Dectin-2 functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses through dendritic cell activation.
Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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