Thermo Fisher Scientific Phospho-C/EBP alpha (Thr222, Thr226) Polyclonal Antibody
C/EBPα 단백질의 Thr222/226 인산화 부위를 인식하는 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 보존제 무첨가 액상 형태로 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr222/226 of mouse C/EBPα |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 278 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977555 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other phosphorylated C/EBP isoforms.
Target Information
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors—alpha, beta, delta, and epsilon—are widely expressed proteins found in various tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L)KXEP.
One of the major roles of these transcription factors is metabolic regulation in liver and fat cells. Studies suggest that they act in a cascade aiding in the development of adipose cells.
Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation sites and display distinct functions in gene regulation.
C/EBPs have also been implicated in nerve growth factor mediation, synaptic plasticity regulation, and inflammatory response in Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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