Thermo Fisher Scientific NFkB p50/p105 Polyclonal Antibody
NFkB p50/p105 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP, ChIP 등 다양한 응용에 적합합니다. Human 및 Non-human primate 반응성을 가지며, 고순도의 Affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | - |
| ChIP assay (ChIP) | 1:25 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids at the amino-terminus of human NF-kappaB p50/p105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 258 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981311 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NF-kB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates multiple cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal RHD region with nuclear localization signal, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65 to create the functional NF-kB complex, directing nuclear translocation and DNA binding. NF-kB has been implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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