Thermo Fisher Scientific CD8 alpha Recombinant Rabbit Monoclonal Antibody (BLR173J)
Thermo Fisher의 CD8 alpha Recombinant Rabbit Monoclonal Antibody (BLR173J)는 마우스 CD8α 단백질을 표적으로 하는 고특이 항체로, WB, IHC, IP에 적합합니다. HEK293F 발현 시스템에서 제조된 정제된 액상 항체로, FFPE 조직에서 citrate buffer(pH 6.0)로 항원 회복을 권장합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 12 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR173J |
| Immunogen | Recombinant protein representing the extracellular domain of mouse T-cell surface glycoprotein CD8 alpha (residues 28–194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin family of receptors. It plays an essential role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
CD8α is crucial for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers of CD8α.
Binding of MHC-I/peptide complexes on antigen-presenting cells (APCs) triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are vital for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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