Thermo Fisher Scientific B7-H3 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가지는 Rabbit Polyclonal Antibody로, B7-H3 (CD276) 단백질 검출에 적합. Western Blot과 IHC(Paraffin)에서 사용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD276 (Accession Q5ZPR3), corresponding to amino acid residues F120–G170 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903301 |
Product Specific Information
Antibody detects endogenous levels of total CD276.
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and selectively stimulates interferon gamma production. Expression can be induced on dendritic cells and monocytes by inflammatory cytokines, and is widely expressed in peripheral tissues such as heart, kidney, testis, and colon. In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing. CD276 has therapeutic potential for regulating cell-mediated immune responses to cancer, especially in combination with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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