Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI2G6), TrueMAB
GEMIN8 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화됨. 인간 유래 GEMIN8 전장 재조합 단백질로 면역화. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G6 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are the building blocks of the spliceosome. It is essential for splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of snRNA to create the core snRNP.
In the cytosol, Sm proteins are held in an inactive 6S pICln-Sm complex by chaperone CLNS1A. The SMN complex dissociates CLNS1A and transfers Sm proteins to the SMN-Sm complex, initiating core snRNP assembly and nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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