Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI1E5), TrueMAB
GEMIN8 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC(Paraffin) 분석에 적합. 인간 시료에 반응하며, 고순도의 액상 형태로 제공. -20°C에서 보관하며 반복 동결·해동은 피해야 함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E5 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. It is essential for the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that assemble in a heptameric ring on the Sm site of small nuclear RNA to form the core snRNP. In the cytosol, Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A from these proteins and facilitates their transfer to an SMN-Sm complex, triggering core snRNP assembly and nuclear transport.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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