Thermo Fisher Scientific XBP1 Recombinant Rabbit Monoclonal Antibody (JM10-62)
XBP1 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. 높은 특이성과 재현성을 제공하며, Protein A 정제 및 안정한 보관 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM10-62 |
| Immunogen | Recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898973 |
Target Information
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA-binding partner of a viral transactivator.
Upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and produces the isoform XBP1(S), a functionally active transcription factor. The unspliced isoform, XBP1(U), is constitutively expressed and functions as a negative feedback regulator of XBP1(S), shutting off transcription of target genes during ER stress recovery. A pseudogene of XBP1 has been identified on chromosome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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