Thermo Fisher Scientific P-Selectin Recombinant Rabbit Monoclonal Antibody (JM10-95)
Rabbit monoclonal antibody targeting human P-Selectin (CD62P), validated for WB, IHC, and ICC applications. Recombinant expression in HEK293 cells, purified via Protein A. Supplied as liquid form, 1 mg/mL, for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM10-95 |
| Immunogen | Synthetic peptide within human CD62P (aa 796–830) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898976 |
Target Information
P-selectin (also known as Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein that regulates cell rolling. It is stored in the Weibel-Palade bodies of endothelial cells and in α-granules of platelets, and can be rapidly translocated to the cell surface upon stimulation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or adenosine diphosphate.
During platelet activation and degranulation, P-selectin redistributes to the plasma membrane and mediates interactions between activated endothelial cells or platelets and leukocytes. It plays a key role in adhesive processes between leukocytes and endothelial cells, acting as a calcium-dependent receptor for sialylated Lewis blood group carbohydrate antigens on neutrophils and monocytes. P-selectin is constitutively expressed during inflammation and contributes to atherogenesis, thrombosis, and tissue destruction. Clinically, it is used to distinguish heparin-induced thrombocytopenia with and without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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