Thermo Fisher Scientific ADAM10 Polyclonal Antibody

Thermo Fisher Scientific ADAM10 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• Positive control: Jurkat whole cell lysates
• Store at 4ºC short term. For extended storage aliquot and store at -20ºC. Avoid freeze-thaw cycles.
• DO NOT store below -22°C.

Target Information

Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to inflammatory responses and programmed cell death. The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma. TNF-α, Notch, and its ligand delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (a disintegrin and metalloprotease), has been identified to cleave TNF-α, Notch, and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.