Thermo Fisher Scientific Phospho-SHP2 (Ser576) Polyclonal Antibody
SHP2 단백질의 Ser576 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunocytochemistry에 사용 가능. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로 세포 신호 조절 및 질병 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human SHP2 that contains serine 576. The sequence is conserved in mouse, rat, and chicken. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533680 |
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction with its substrates.
It is widely expressed in most tissues and plays a regulatory role in cell signaling events important for mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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