Thermo Fisher Scientific Phospho-SHP2 (Tyr580) Polyclonal Antibody
인간과 마우스에서 반응하는 Phospho-SHP2 (Tyr580) 폴리클로날 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, BSA가 포함된 PBS 용액 형태로 제공됩니다. 세포 신호전달 및 PTP 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Publications
- Miscellaneous PubMed (Misc): None
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Dog |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human SHP2 that contains tyrosine 580. The sequence is conserved in mouse, rat and chicken. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533681 |
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, which mediate phospho-tyrosine binding and substrate interactions. It is widely expressed and plays a regulatory role in cell signaling events crucial for mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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