Thermo Fisher Scientific IL9R Monoclonal Antibody (33423)

Applications and Tested Dilution

Product Specifications

Product Specific Information

The Neutralization Dose50 (ND50) for anti-human IL9R is approximately 2–4 µg/mL in the presence of 2 ng/mL of recombinant human IL9 using human MO7e cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Human Interleukin 9 (IL9) was first identified based on its proliferative activity on a human myeloid leukemic cell line. Human IL9 stimulates the proliferation of the human megakaryocytic leukemic cell line M07e. Human IL9 supports erythroid colony formation and synergizes with IL4 in the production of IgE and IgG.
The interleukin 9 receptor (IL9R) is a member of the hematopoietin receptor superfamily. The cDNAs encoding mouse and human IL9 receptors have been isolated. The deduced mouse and human transmembrane proteins, sharing 53% amino acid sequence identity, contain 468 and 533 amino acid residues, respectively.
A number of isoforms of IL9R, including a putative soluble form, have also been identified. The IL9 receptor is expressed in various hematopoietic cells including T cells, neutrophils, mast cells, and macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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