Thermo Fisher Scientific Phospho-JAK2 (Tyr1007) Polyclonal Antibody
Phospho-JAK2 (Tyr1007) 폴리클로날 항체로 인간, 마우스, 랫트 샘플에서 JAK2의 인산화 상태를 검출. Western blot, IHC, ICC/IF에 사용 가능. 고순도 정제, 액상 형태로 안정적이며 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2 (Accession O60674), corresponding to amino acid residues around phosphorylated Tyr1007 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818274 |
Product Specific Information
Antibody detects endogenous levels of JAK2 only when phosphorylated at Tyrosine 1007.
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. JAK2 contains the catalytic domain (JH1), and its activation leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate gene transcription. JAK2 is required for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Mutations in JAK2 are associated with Budd-Chiari syndrome, polycythemia vera, thrombocythemia 3, myelofibrosis, and acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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