Thermo Fisher Scientific HSF2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  MLSGRQFSID PDLLVDLFTS SVQMNPTDYI NNTKSENKGL ETTKNNVVQP VSEEGRKSKS KPDKQLIQYT AFPLLAFLDG NPASSVEQAS TTASSEVLSS VDKPIEVDEL LDSSLDPEPT QSKLVRLEPL TEAEASEATL FYLCELAPAP LDSDMPLLDS

• Positive Samples:
  U-87MG, LO2, HeLa, Mouse heart, Rat liver, Rat testis

• Cellular Location:
  Cytoplasm, Nucleus

Target Information

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated as heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation.
HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein levels. HSF1 is normally a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA-binding activity, and translocates to the nucleus.
HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.