Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI2C4), TrueMAB
NUMB 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot과 유세포 분석에 적합합니다. 재조합 인간 NUMB 단백질을 면역원으로 사용하였으며, 동결건조 형태로 제공됩니다. 연구용으로 세포 분화 및 신경세포 성장 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C4 |
| Immunogen | Full length human recombinant protein of human NUMB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that regulates the differentiation of neuronal progenitor cells.
It functions in clathrin-dependent endocytosis by binding to the AP-2 complex and is expressed in postmitotic neurons, where it plays a role in axonal growth.
Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domains exhibit extensive neurite outgrowth, which can be inhibited by voltage-gated Ca²⁺ channel (VGCC) inhibitors or Ca²⁺ chelators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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