Thermo Fisher Scientific PSMD8 Polyclonal Antibody
Thermo Fisher Scientific의 PSMD8 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 Western blot, IHC, ICC/IF 등에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체로 단백질 분해 복합체 연구에 적합. 장기 보관 시 -20°C에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PSMD8. Recombinant protein control fragment (Product #RP-89240). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646074 |
Product Specific Information
Immunogen sequence:
NRVAEFHTEL ERLPAKDIQT NVYIKHPVSL EQYLMEGSYN KVFLAKGNIP AESYTFFIDI LLDTIRDEIA GCIEKAYEKI LFTEATRILF FNTPKKMTDY AKKRGWVLGP NNYYSFASQQ QKPEDTTIPS TELAKQVIEY ARQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 97%
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.
The 20S core consists of four rings of 28 non-identical subunits (two rings of 7 alpha subunits and two rings of 7 beta subunits).
The 19S regulator includes a base (6 ATPase subunits and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits).
Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
A modified proteasome, the immunoproteasome, processes class I MHC peptides.
This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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