Thermo Fisher Scientific POLH Polyclonal Antibody
Thermo Fisher Scientific의 POLH 폴리클로날 항체는 인간 POLH 단백질에 특이적으로 반응하며 IHC 및 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLH. Recombinant protein control fragment (Product #RP-89494) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645749 |
Product Specific Information
Immunogen sequence:
PPLTMLFLCA TKFSASAPSS STDITSFLSS DPSSLPKVPV TSSEAKTQGS GPAVTATKKA TTSLESFFQK AAERQKVKEA SLSSLTAPTQ APMSNSPSKP SLPFQTSQST GTE
Ortholog sequence identity:
- Mouse: 63%
- Rat: 61%
Target Information
The XPA gene encodes a zinc metalloprotein that binds to DNA damaged by UV radiation and chemical carcinogens, essential for the incision step during nucleotide excision repair.
The XPB and XPD genes encode DNA helicases involved in DNA repair and transcription.
The XPG gene product is an endonuclease that cuts on the 3′ side of a DNA lesion during nucleotide excision repair.
Molecular defects in the XP variant (POLH) group maintain normal excision repair but reduce the ability to synthesize intact daughter DNA strands after DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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