Thermo Fisher Scientific p21 Monoclonal Antibody (A8C12)
인간 p21 단백질을 인식하는 마우스 단클론 항체로, IHC(P)에서 1:400 희석 비율로 검증됨. 단백질 A로 정제된 액상 형태이며, PBS 버퍼에 보존. 세포 내 핵 및 세포질에서 p21 발현 연구에 적합. 종양 억제 및 세포주기 조절 관련 연구용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8C12 |
| Immunogen | Recombinant protein within full length of human p21 (aa 1–164/164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091234 |
Product Specific Information
- Positive control: Human cervical well-differentiated squamous cell carcinoma tissue, human thyroid carcinoma tissue
- Predicted band size: 16 kDa
- Subcellular Location: Nucleus, Cytoplasm
Target Information
Protein p21 is a tumor suppressor protein that inhibits cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
p21 plays an essential role in the cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking the G1/S and G2/M transitions after DNA damage to allow repair.
In the cytoplasm, p21 exhibits anti-apoptotic activity by binding and inhibiting caspase 3, ASK1, and JNK.
This dual function contributes to both tumor suppression and oncogenic processes depending on cellular context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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