Thermo Fisher Scientific p21 Monoclonal Antibody (A8C11)
인간 p21 단백질을 타겟으로 하는 Mouse IgG2a 단클론 항체. IHC(P)에서 1:200~1:400 희석으로 사용 가능. 핵 및 세포질 내 p21 검출에 적합하며, 단백질 A로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8C11 |
| Immunogen | Recombinant protein within full length of human p21 (aa 1–164/164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3091230 |
Product Specific Information
- Positive control: Human cervical well-differentiated squamous cell carcinoma tissue, human thyroid carcinoma tissue, human breast carcinoma tissue
- Predicted band size: 16 kDa
- Subcellular Location: Nucleus, Cytoplasm
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and acts as a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking the transition from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 exhibits anti-apoptotic activity by binding to and inhibiting caspase 3, ASK1, and JNK. Thus, p21 has dual roles in carcinogenesis, functioning both as a tumor suppressor and an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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