Thermo Fisher Scientific GNA13 Recombinant Rabbit Monoclonal Antibody (JE63-76)
GNA13 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, WB 및 IHC(P) 실험에 적합. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE63-76 |
| Immunogen | Recombinant protein within human GNA13 aa 278–377/377 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931257 |
Target Information
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, 16787920, 16705036, 27084452).
GNA13 activates effector molecule RhoA via RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, ARHGEF12/LARG) (PubMed:15240885, 12515866).
GNA13-dependent Rho signaling regulates transcription factor AP-1 and promotes tumor cell invasion and metastasis through RhoA/ROCK pathway (PubMed:16787920, 16705036, 27084452).
It also inhibits CDH1-mediated cell adhesion independently of Rho activation (PubMed:11976333).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 내용: GNA13 항원 구조 및 위치 정보)
- MA5-44800_GNA13_Q14344-1_Rabbit.svg
- MA5-44800_GNA13_Q14344-1_Rabbit_PDP.jpeg
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