Thermo Fisher Scientific PTPRN Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA564913 | - | Thermo Fisher Scientific PA564913 PTPRN Polyclonal Antibody 100 ul pk | 재고문의 | pk | 794,000원 | - | 873,400원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Immunocytochemistry (ICC/IF)
0.25-2 µg/mL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PTPRN. Recombinant protein control fragment (Product #RP-88661). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
PTPRN,
uniProtId:
Q16849-1,
ncbiNodeId:
9606,
antigenRange:
259-371,
antigenLength:
979,
antigenImageFileName:
PA5-64913_PTPRN_Q16849-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-64913_PTPRN_Q16849-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663398
Product Specific Information
Immunogen sequence: HSYGDLPGPSP AQLFQDSGLL YLAQELPAPS RARVPRLPEQ GSSSRAEDSP EGYEKEGLGD RGEKPASPAV QPDAALQRLA AVLAGYGVEL RQLTPEQLST LLTLLQLLPK GA
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 81%.
Target Information
IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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