Thermo Fisher Scientific HOXA11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human HOXA11. Recombinant protein control fragment (Product #RP-105707). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOXA11,uniProtId:P31270-1,ncbiNodeId:9606,antigenRange:51-143,antigenLength:313,antigenImageFileName:PA5-64911_HOXA11_P31270-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64911_HOXA11_P31270-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662777

Product Specific Information

Immunogen sequence: LPQVQPVREVT FREYAIEPAT KWHPRGNLAH CYSAEELVHR DCLQAPSAAG VPGDVLAKSS ANVYHHPTPA VSSNFYSTVG RNGVLPQAFD QF

Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

Target Information

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.