Thermo Fisher Scientific HOXA11 Polyclonal Antibody
HOXA11 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. 인간 시료에 반응하며 ICC/IF 등 다양한 연구용 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었고, PBS 및 글리세롤 완충액에 보존됩니다. 연구용 전용 제품입니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HOXA11 (Recombinant protein control fragment, Product #RP-105707) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662777 |
Product Specific Information
Immunogen sequence:
LPQVQPVREVT FREYAIEPAT KWHPRGNLAH CYSAEELVHR DCLQAPSAAG VPGDVLAKSS ANVYHHPTPA VSSNFYSTVG RNGVLPQAFD QF
- Highest antigen sequence identity to the following orthologs: mouse 100%, rat 100%
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region.
It encodes a homeobox-domain containing protein, HOX11, with a glycine and proline-rich amino terminus.
HOX11 is required for maintenance of the developing spleen and cell survival.
The HOX11 protein binds to a specific DNA sequence and localizes to the cell nucleus, acting as a positive transcription activator.
The HOX11 gene is highly expressed in T-ALLs due to translocations t(7;10)(q35;q24) or t(10;14)(q24;q11).
Such translocations deregulate the homeobox gene, activating tumor-associated target genes.
HOX11 gene translocation has been linked to T-cell leukemia and lymphoid neoplasias.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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