
Thermo Fisher Scientific Cullin 3 Polyclonal Antibody
Western blot 및 IHC(PFA)에서 Human, Mouse, Rat 시료의 CUL3 단백질을 검출하는 Rabbit Polyclonal Antibody. 합성 펩타이드 면역원 사용, 액상 형태로 1 mg/mL 농도. Affinity chromatography로 정제되어 높은 특이성과 재현성 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CUL3 (Accession Q13618), corresponding to amino acid residues N560–K610. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899701 |
Product Specific Information
Antibody detects endogenous levels of total CUL3.
Target Information
Cullin 3 (CUL3) is a member of the human cullin gene family (CUL1, 2, 3, 4a, 4b, and 5), homologous to the S. cerevisiae cdc53 gene. CUL1 forms a complex with human p19 skp1 and F-box protein p45 skp2, participating in ubiquitin ligase-mediated proteolysis of G1 cell cycle regulatory proteins.
In contrast, CUL2 forms a complex with the transcriptional elongation complex SIII (Elongin C, Elongin B, and VHL), though its function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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