Thermo Fisher Scientific CUG-BP2 Polyclonal Antibody
CUG-BP2 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. Human, Mouse, Rat 반응성을 가지며 Rabbit IgG로 제작되었습니다. 고순도 Affinity chromatography 정제, 액상 형태로 -20°C 보관합니다.
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Thermo Fisher Scientific CUG-BP2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- 1:500–1:2,000
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CELF2 (Accession O95319), corresponding to amino acid residues S76–S126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899700 |
Product Specific Information
Antibody detects endogenous levels of total CUGBP2.
Target Information
CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50.
CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor.
CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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