Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (SPM423)
인간 및 비인간 영장류 반응성의 HLA-DRB(MHC II) 단일클론 항체로, 다양한 면역학적 분석(WB, IHC, ICC, Flow)에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, PBS 버퍼에 보존. 연구용으로 면역항원 제시 관련 연구에 적합.
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Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (SPM423)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM423 |
| Immunogen | Activated human peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Mouse.
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, a member of the human leukocyte antigen (HLA) class II molecule family. The HLA-DR beta chain is encoded by the HLA-DRB gene and is primarily expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.
These cells capture, process, and present antigens to T cells, facilitating immune recognition. HLA-DR beta plays a critical role in presenting antigenic peptides to CD4+ T cells, activating adaptive immune responses. Structurally, HLA-DR beta consists of:
- An extracellular domain containing the peptide-binding groove
- A transmembrane domain anchoring the molecule to the cell membrane
- A cytoplasmic tail involved in intracellular signaling
HLA and MHC antibodies are essential in Immunopeptidomics, enabling the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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