Thermo Fisher Scientific FANCD2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from within residues 1200 - 1300 of Human FANCD2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FANCD2,uniProtId:Q9BXW9-2,ncbiNodeId:9606,antigenRange:1200-1300,antigenLength:1451,antigenImageFileName:PA5-19575_FANCD2_Q9BXW9-2_Rabbit.svg,antigenImageFileNamePDP:PA5-19575_FANCD2_Q9BXW9-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_10980774

Product Specific Information

For Western Blot, this antibody has non-specific bands at 110 kDa,41 kDa and 71 kDa.

Target Information

FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.