Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human FANCD2 protein. Validated for Western blot applications. Involved in DNA repair and chromosomal stability studies. Supplied as unconjugated liquid form with 1.2 mg/mL concentration. For research use only.
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Applications
- Western Blot (WB)
Tested Dilution
- 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from residues 1200–1300 of Human FANCD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10980774 |
Product Specific Information
For Western Blot, this antibody shows non-specific bands at 110 kDa, 41 kDa, and 71 kDa.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is essential for maintaining chromosomal stability and promoting accurate homolog pairing during meiosis. It plays a key role in DNA double-strand break repair through homologous recombination and single-stranded annealing. FANCD2 is required for the targeting and stabilization of BLM at abnormal structures caused by replicative stress and facilitates BRCA2/FANCD1 loading onto damaged chromatin. Mutations in the FANCD2 gene lead to Fanconi anemia complementation group D2, which affects bone marrow elements and results in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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