Thermo Fisher Scientific beta Arrestin 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting beta Arrestin 1 for WB, IHC, ICC, and IP applications. Recognizes multiple species based on sequence homology. Unconjugated, liquid form at 1 mg/mL concentration. Suitable for GPCR signaling and desensitization stud...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| Immunoprecipitation (IP) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from within residues 350–450 of Human beta Arrestin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10986711 |
Product Specific Information
This antibody is predicted to react with rabbit, cow, human, Xenopus laevis, and cynomolgus monkey based on sequence homology.
Target Information
Beta Arrestin 1 is a member of a protein family widely expressed, especially abundant in the central nervous system. It acts as an adaptor or scaffold molecule essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G-protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.
Upon ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated, and GPCRs are internalized, leading to activation of the Ras, Raf, ERK1, and ERK2 signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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