Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI2A5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
It is part of the TNF-receptor superfamily and activates apoptosis signaling through TNFSF10/TRAIL/APO-2L.
Two transcript variants encoding different isoforms and one non-coding transcript have been identified.
Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is highly expressed in lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.