Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI2A5), TrueMAB
TNFRSF10B 단일클론 항체(OTI2A5)는 Human 및 Mouse 반응성을 가지며, Western blot과 IHC(P) 실험에 적합합니다. 무보존제, 동결건조 형태로 제공되며, TRAIL-R2(DR5) 단백질을 표적으로 합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A5 |
| Immunogen | Human recombinant protein fragment (aa 203–411 of human TNFRSF10B) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
It is part of the TNF-receptor superfamily and activates apoptosis signaling through TNFSF10/TRAIL/APO-2L.
Two transcript variants encoding different isoforms and one non-coding transcript have been identified.
Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is highly expressed in lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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