Thermo Fisher Scientific IL-8 (CXCL8) Polyclonal Antibody
IL-8 단백질을 특이적으로 인식하는 다클론 항체로, ELISA 등 연구용 분석에 적합합니다. Sheep 유래 IgG 형식이며, 액상(Unconjugated) 형태로 제공됩니다. -20°C에서 보관하며, 동결/해동은 피해야 합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 5–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant human IL-8 (amino acids 21–99, UniProt ID: P10145-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2242830 |
Product Specific Information
- PA1-75220 specifically detects IL-8.
- Successfully used in ELISA applications.
- Immunogen: Recombinant IL-8.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72-amino-acid pro-inflammatory factor belonging to the CXC chemokine subfamily, binding to IL-8RA and IL-8RB receptors.
IL-8 acts as a chemoattractant and potent angiogenic factor. Its expression can be induced by various inflammatory stimuli in multiple cell types, including macrophages and endothelial cells.
In endothelial cells, IL-8 is stored in Weibel-Palade bodies. Initially isolated from osteosarcoma cells, IL-8 contains the ELR motif (Glu-Leu-Arg) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclatures include NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related chemokines form a gene cluster on chromosome 4q.
IL-8 plays a role in tumor angiogenesis and growth, and in the pathogenesis of bronchiolitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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