Thermo Fisher Scientific Phospho-Tau protein (Ser739) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting Tau functions as a linker protein. Axonal polarity is defined by TAU/MAPT localization in the neuronal cell body domain. Short isoforms allow cytoskeletal plasticity, whereas longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease. Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration in AD. Multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II, phosphorylate Tau. Hyper-phosphorylated Tau is also found in other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.