Thermo Fisher Scientific UCHL1 Monoclonal Antibody (1B8-4D2)
UCHL1 단클론 항체(1B8-4D2)는 인간 UCHL1 단백질을 인식하는 마우스 IgG1 항체로, WB, IHC, ELISA에 적합합니다. 신경세포 특이 단백질 PGP9.5 연구에 유용하며, 신경퇴행성 질환 및 암 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific UCHL1 Monoclonal Antibody (1B8-4D2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–10 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B8-4D2 |
| Immunogen | UCHL1 (AAH00332, 1–223 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA
Target Information
PGP9.5 (Protein Gene Product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and is a member of the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12).
PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate monomers.
It is expressed in neurons, nerve fibers, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells.
Overexpression is associated with non-small cell lung cancer, while decreased expression correlates with Huntington and Alzheimer diseases.
PGP9.5 serves as a neuronal marker and is valuable in neurodegenerative disorder studies, including Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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