Thermo Fisher Scientific UBE3A Monoclonal Antibody (3E5)
UBE3A 단백질을 인식하는 Thermo Fisher의 단일클론 항체로, Western blot 및 ELISA에 적합합니다. Human 종에 반응하며, Mouse IgG2a 아이소타입입니다. 고순도 친화 크로마토그래피 정제 제품으로, 연구용으로 안정적이고 재현성 높은 결과를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E5 |
| Immunogen | UBE3A (AAH09271, 51 a.a. approximately 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ETFQQLITYK VISNEFNSRN LVNDDDAIVA ASKCLKMVYY ANVVGGEVDT NHNEEDDEEP IPESSELTLQ ELLGEERRNK KGPRVDPLET ELGVKTLDCR
Target Information
UBE3A (ubiquitin-protein ligase E3A, also known as E6AP) is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 conjugating enzyme to its substrates. Known substrates include ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, PML tumor suppressor, and CDKN1B.
UBE3A may act as a cellular quality control ligase by aiding degradation of misfolded cytoplasmic proteins and plays a role in circadian clock regulation.
Defects in UBE3A are associated with Angelman syndrome (AS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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