Thermo Fisher Scientific Phospho-IRF3 (Ser14) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of IRF3 only when phosphorylated at Ser14.

Target Information

IRF3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IRF3 regulates transcription of type I IFN genes (IFN-α and IFN-β) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-β gene than the IFN-α gene and is crucial in both early and late phases of IFNA/B gene induction. IRF3 is inactive in the cytoplasm of uninfected cells and becomes phosphorylated by IKBKE and TBK1 kinases upon viral infection or toll-like receptor signaling, leading to dimerization, nuclear localization, and complex formation with CREB binding protein to activate transcription of type I IFN and ISG genes. Mutations in IRF3 may result in acute, infection-induced encephalopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)