Thermo Fisher Scientific SKP1 Polyclonal Antibody
SKP1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 사람, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 항체로, -20°C 보관. 연구용으로 단백질 분해 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SKP1 (Accession P63208), corresponding to amino acid residues A52–E102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852028 |
Product Specific Information
Antibody detects endogenous levels of total Skp1.
Target Information
This gene encodes a component of SCF complexes, which include this protein, cullin 1, a ring-box protein, and an F-box family member. SKP1 binds directly to the F-box motif in F-box proteins. SCF complexes regulate ubiquitination of specific protein substrates, targeting them for proteasomal degradation. These substrates include regulators of cell cycle progression and development. SKP1 also functions as an RNA polymerase II elongation factor. Alternative splicing produces two transcript variants, and a related pseudogene exists on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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