Thermo Fisher Scientific CaMKIV Polyclonal Antibody
Rabbit polyclonal antibody against human CaMKIV, validated for Western blot. Recognizes recombinant fragment (aa 1–216). Predicted cross-reactivity with multiple species. Supplied as liquid, antigen affinity purified, for research use only.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–216 of Human CaMKIV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.22 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546062 |
Product Specific Information
- Recommended positive control: Raji
- Predicted reactivity: Mouse (95%), Rat (94%), Zebrafish (89%), Xenopus laevis (91%), Chicken (88%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is involved in transcriptional regulation in lymphocytes, neurons, and male germ cells. The nuclear localization of CaMKIV supports its role in calcium-dependent gene expression. It is abundant in testis, T-cells, and neurons, and contributes to synaptic plasticity and calcium signaling. In testes, CaMKIV associates with chromatin, suggesting a role in chromatin remodeling during spermatid nuclear condensation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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